After being attacked by one of my clients yesterday i feel a bit fragile and in need of a holiday, or at least some time away. This morning the Professor Leary put to me the idea that we go looking for this strange anti cancer fungus that grows outta snails in Tibet to sell in Hong Kong. We calculated it would be a two-week trip, and we would make a small profit as well a noble cause. It was an interesting idea, got me feeling all Bill Burroughs. Well who knows, maybe we need to do more research; anyways it was a good conversation as usual, politics, travelling to dangerous places, religion, and art and last but most importantly smart drugs. Yeah we have uncovered a new drug that appears to be very interesting. Its called Nexus on the streets, but it is known as 2C-B.

A cross between mescaline, MDMA, and speed, but not too much of each. A perfect combo that you can eat, drink but not sleep for 6 hours. Doesn't wear you out. No hangover. There is increased body awareness of every kind, including skin sensitivity, heightened responsiveness to smells, tastes, and sexual stimulation. Mmmm baby.
Doses are 12-24mg, Duration is 4-8 hours. Doses of 100mg have been taken safely. 2C-B seems to be an extraordinarily colourful hallucinogen similar to LSD -- apparently somewhat analytical and disassociate in higher doses or in those sensitive to those effects.
Quote from Ecstasy: The MDMA Story... [begins with a quotation from Alexander Shulgin]: 2C-B... is a tool... which ties the mental processes directly and constructively into the physical soma. The analgesic effects experienced with many, if not most, psychedelic drugs, are not present with 2C-B.
One experiences increased consciousness of physical health and energy, or, on the other hand, sharpened awareness of any body imbalance or discomfort. 2C-B allows for rich visual imagery and intense eyes- closed fantasy without the cluttering up of the mental field with too much elaboration... It is a superb tool for learning and growth.
[...] At high doses (above 30 mgs.), 2C-B is intensely hallucinogenic, and, like any major psychedelic, can be frightening for certain people. In small doses, it becomes a mild sensory enhancer but does not have the strongly empathogenic qualities that MDMA has.
Perhaps the best use that has been found for 2C-B is as a synergist with MDMA. When taken together, the MDMA pushes the non-specific 2C-B reaction in a more warm and empathetic direction. Because 2C-B is a psychedelic drug, and therefore not fully predictable, its action can take the user in many different directions. But if the set and setting are right, 2C-B can enhance the desire for sexual orgasm during an MDMA experience. The synergy of the two substances can on occasion be a true aphrodisiac.
Shulgin writes in PiHKAL:
"The most successful reports have followed a program in which the two drugs are not used at the same time, nor even too closely spaced. It appears that the optimum time for the 2C-B is at, or just before, the final baseline recovery of the MDMA."
And here's what Erowid has to say on the subject:

The effects of 2C-B have been described as a cross between the effects of LSD and MDMA, but that it is nothing like a combination of the two. It is mildly psychedelic, much less mind-expanding or dissociative than mushrooms or LSD, but much less directed than MDMA.
2C-B includes Open Eye Visual (OEV) effects, which are usually described as crawling, shifting, or undulating, or cartooning. Closed Eye Visuals (CEVs) are present and increase with dosage. Many report a 'colour shift' where objects seem to have red / green halos around them.
2C-B has a large 'body' component which some describe as "body tripping." Shulgin and others say that 2C-B can bring body-issues forward or make them more prominent and, in this way, some people say it can be a self-diagnostic tool for bodywork. Many, but not all, people experience stomach discomfort sometimes including mild diarrhoea, gas, nausea and (rarely) vomiting. One user has reported a very a recurrent effect of increased mucus production at the base of the trachea, causing constant coughing during the effects of 2c-b, pseudoephedrine seems to clear this up.
In general, 2C-B has a somewhat 'positive' mood push as well as a mild stimulant effect, but it is far less stimulating and far less forcefully positive than MDMA. Some people find they can sleep once the peak is over (about 60-90mins after the effects start).
Most people experience 2C-B as being much 'lighter' on their body than MDMA with far less 'crash' and much less physically draining. It is also not as 'easy' as MDMA, in that it is more of a 'true' psychedelic -- allowing the users mind to become manifest and create the experience instead of being 'pushed' into a positive mood space as MDMA usually does.
Some people find the stimulating and body effects to combine in a way that is sensual or sexual and Shulgin has said that if an effective aphrodisiac is every discovered, it will probably be patterned after 2C-B. Many people, however, find it very un-sexy with the body effects being experienced as somewhat disquieting.
Some people find 2C-B increases their ability to communicate verbally, while others find themselves unable to elucidate their ideas clearly. Some people describe a type of confusion that can be part of the experience, a type of 'stoned' feeling of mental and physical relaxation or floppiness which can translate in inability or lack of desire to go into complex intellectual processes.
2C-B at medium and low doses has the interested character that it is often quite easy to move into and out of -- that going from feeling very involved in the experience to feeling quite 'sober' can be very fast and sometimes unexpected. Some people describe 2C-B as being more 'plastic' or 'malleable' than other psychedelics because one can learn to manipulate the depth of the effects.
2C-B can be used in some of the same ways MDMA is used for working through interpersonal issues and dealing with emotional conflicts.
'Inappropriate' smiling or giggling is common with 2C-B and other psychedelics.
As with all psychedelics, many people experience the coming up period as being somewhat cold and shivery.
As dose increases, the chance for feelings of fear and uncertainty increase.
As with other entheogens, it is unsafe to drive or use dangerous equipment with 2C-B because it affects attention span, visual acuity, concentration, and coordination. If you work with 2C-B, plan your entheogen experiences carefully and think ahead so you don't ever find yourself needing to drive during the experience.

Well we may be able to swap a bag of sage for some 2CB in the near future, i'd like to try it, in the meantime, i am hunting high and low for my dmt, which like all my herbs seems to get misplaced in the clutter of Mission Control, one day I am going to uncover the mother load and have a shamanic wig out.
Reading my new book called Supernatural, by Graham Hancock, who also wrote Fingerprints of the Gods, a fascinating theory that suggests Inca, Mayan and Olmenec Cultures all share the same mythology, all involve aliens in space suits, flying in hover machines and shooting ray guns. He also suggests that all architecture from these civilizations were in fact built as solar calendars to indicate the cycle of civilization, currently about to restart 12 June 2012, not long now folks. Anyway it is a good read, Supernatural takes a look at dmt in art, religion and the human evolutionary leaps. It's quite interesting and a whole lot better than the spirit molecule, which i have to say was a disappointing read and research that really does little to impressed the continued use of psychedelics.